We are seeking a lab based senior scientist to support the DMPK operations. This person will be supporting immuno-oncology (IO) large molecule preclinical development program in in vitro immunology assays, nonclinical PK, PK/PD, pharmacology and toxicology studies, and the mechanistic/quantitative system pharmacology (QSP) This person will participate in designing, execution and analysis of the experimental studies, immunology assay development, qualification, and in vitro and/or ex in vivo sample analysis of receptor abundance, turnover, and occupancy in cells and tissues. The candidate will collaborate with internal and external resources to build an experiment – based platform for the mechanistic/quantitative pre-clinical to clinical translation research on large molecule development candidate human dose and receptor occupancy prediction.
·Design, develop and implement experimental studies to determine receptor abundance, turnover, and occupancy in vitro in different types of immune cells and ex in vivo of samples from PK/PD, pharmacology and toxicology studies.
·Independently analyze, interpret, document and communicate study results to the department and project teams.
·Collaborate with other relevant functional groups and external resources to improve the assays and determination of key parameters to support mechanistic/quantitative system pharmacology modeling and human dose/receptor occupancy prediction of immuno-oncology large molecule preclinical development program
•PhD degree with 0+ years or masters degree with 3+ years of relevant working experience in biology, immunology, biochemistry, pharmacology, pharmaceutical sciences or equivalent area.
•Knowledge and expertise in molecular and cellular biology, immunology, pharmacology or familiar with new discovery and findings in Immuno-oncology space.
•Experimental expertise in basic immunology and biology assays, such as flow cytometry, ligand binding based assays, membrane receptor characterization, immunohistochemistry assays, and extensive primary cell and cell-line culture experience.