We are seeking an experienced and driven immunologist or cellular biologist to help build and advance our BOXR cell therapy portfolio. The selected candidate will lead a drug discovery program from initiation to clinical application. The successful candidate will have extensive knowledge of T cell biology and the challenges of the solid tumor environment. This position is in a highly innovative and rapidly evolving environment and interfaces with multiple teams and functions across the company.
Key Activities and Responsibilities:
- Generation, analysis, and interpretation of key in vitro data to identify optimal binders and BOXR transgenes for lead selection of BOXR T cell candidates against various solid tumor indications.
- Design and execute novel strategies to enhance the function of adoptive T cell therapies in the solid tumor microenvironment.
- Independently design, develop, and perform cell-based functional assays to evaluate mechanism of action of therapeutic candidate in exhaustion and suppression assays.
- Prepare study reports, present results internally at team meetings and externally with collaborators.
- Participate in the development of scientific manuscripts and abstracts, present scientific results at conferences.
- Perform literature searches/reviews as necessary.
- Keep a study record by maintaining a detailed, accurate laboratory notebook.
- Supervise and mentor research associate/associate scientist.
- Other duties as assigned
Competences, Skills and Qualification:
- An independent, flexible, high-energy expert in immunology or cancer biology
- PhD with at least 5 years of relevant industry or MS and at least 8 years of experience in a biopharmaceutical setting, or equivalent
- Significant prior experience with primary human cells, especially T cells, highly desirable. Industry experience with CAR-T cells preferred
- Solid understanding of tumor biology and the immunosuppressive tumor microenvironment
- Familiarity with lentiviral or retroviral production and transduction of mammalian cells
- High level of expertise in assays characterizing T cell phenotype and function, including but not limited to cytotoxicity, proliferation, cytokine production, chemotaxis, multiparameter immunophenotyping, and NGS analysis
- Demonstrated leadership and innovative intellectual contributions to a project
- Demonstrated scientific productivity, as evidenced by strong publication record
- Comfortable in a fast-paced small company environment with minimal direction and able to adjust workload based upon changing priorities
- Strong organizational and record-keeping skills
- Excellent interpersonal, verbal and written communication skills
- Prolonged periods of sitting at a desk, standing in a lab and working on a computer.
- Ability to safely travel to various physical locations.
- Must be able to lift 15 pounds at times.