Our client is seeking a scientist to be a part of an integrated computational/experimental biology team to identify and validate novel oncology and immuno-oncology targets in the area of chromatin-mediated transcriptional regulation.
The ideal candidate will have a strong background in cancer biology and genetic manipulation/genome editing, and a desire to contribute to an evolving and diverse drug discovery pipeline.
- Understanding cancer genomics and epigenomics data and formulating testable hypotheses about targets and their link to disease biology
- Designing and executing genetic perturbation or genome editing studies to validate the function of target genes or gene control elements in relevant experimental systems
- Working with colleagues in a variety of functional groups to support studies in discovery biology
- Reading and staying on top of the latest and greatest chromatin biology, functional genomics, and cancer genetics literature to identify new therapeutic opportunities
- Opportunities to communicate data to broad scientific audiences at internal meetings and external conferences
- Ph.D. in life sciences with emphasis on cell or molecular biology
- Deep knowledge and laboratory research experience in cancer signaling and transcriptional networks as demonstrated by peer-reviewed publications
- Direct experience with genetic perturbation techniques, including CRISPR/Cas9, RNAi, and overexpression
- Ability to work independently in planning, executing and interpreting data and to execute projects in parallel
- Flexibility to work in a multidisciplinary team environment and to interact across functional groups
- Understanding of current scientific literature and willingness to explore new areas
- Strong oral and written communication skills