LC-MS Analytical Chemist – Metabolomics

The Role:

Our client located in Cambridge is seeking a scientist with a proven track record of successfully operating in a demanding drug discovery environment.

The successful candidate will develop and execute mass spectrometry-based metabolomic and targeted metabolite analyses to support target identification and drug program efforts.

Major Responsibilities:

• Develop  quantitative LC-MS methods for the targeted analysis of individual or small sets of metabolites.
• Efficiently design and perform metabolomics and targeted metabolite analyses in collaboration with project team members.
• Analyze, compile, and communicate the results of studies on a regular basis in project team meetings.
• Productively communicate the value of new methods and results within the company, interact with peers in the cellular metabolism group, and as a collaborator with both immunology and drug discovery teams.
• External communication at scientific conferences and meetings is expected.

Requirements and Qualifications:

Education:

• BS or MS in Analytical Chemistry or a closely related field

Required Experience:

• Minimum of 5-8 years of industry experience
• Strong track record in the development of mass spectrometry-based methods for quantitating small molecules and metabolites
• Mass spec data processing, analysis, and organizational capabilities are central to the position; beyond operation of commercial mass spec software, this will include extensive use of Spotfire, as well as in-house proprietary software packages
• Biomarker discovery and DMPK experience desirable
• Experience in mass spec instrumentation as it relates to metabolomics, lipidomics, and associated data analysis is desirable
• Experience with LIMS systems is desirable
• Familiarity with stable isotope tracing is desirable

• Desirable skill-sets include familiarity with various mass spec software packages and analytic techniques with QToF, Q-Exactive, and TripleToF instrumentation