LC-MS Analytical Chemist - Metabolomics | ClinLab Staffing

The Role:

Our client located in Cambridge is seeking a scientist with a proven track record of successfully operating in a demanding drug discovery environment.

The successful candidate will develop and execute mass spectrometry-based metabolomic and targeted metabolite analyses to support target identification and drug program efforts.

Major Responsibilities:

  • Develop  quantitative LC-MS methods for the targeted analysis of individual or small sets of metabolites.
  • Efficiently design and perform metabolomics and targeted metabolite analyses in collaboration with project team members.
  • Analyze, compile, and communicate the results of studies on a regular basis in project team meetings.
  • Productively communicate the value of new methods and results within the company, interact with peers in the cellular metabolism group, and as a collaborator with both immunology and drug discovery teams.
  • External communication at scientific conferences and meetings is expected.

Requirements and Qualifications:


  • BS or MS in Analytical Chemistry or a closely related field

Required Experience:

  • Minimum of 5-8 years of industry experience
  • Strong track record in the development of mass spectrometry-based methods for quantitating small molecules and metabolites
  • Mass spec data processing, analysis, and organizational capabilities are central to the position; beyond operation of commercial mass spec software, this will include extensive use of Spotfire, as well as in-house proprietary software packages
  • Biomarker discovery and DMPK experience desirable
  • Experience in mass spec instrumentation as it relates to metabolomics, lipidomics, and associated data analysis is desirable
  • Experience with LIMS systems is desirable
  • Familiarity with stable isotope tracing is desirable
  • Desirable skill-sets include familiarity with various mass spec software packages and analytic techniques with QToF, Q-Exactive, and TripleToF instrumentation


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